Veripath Test Directory

Epic Test Name Rivaroxaban Assay
Synonyms Rivaroxaban Anti-Xa assay
Description Rivaroxaban is an oral Factor Xa inhibitor that is used for long-term anticoagulation in patients with atrial fibrillation, and for the treatment deep vein thrombosis (DVT) or pulmonary embolism (PE). Although routinely Rivaroxaban does not need to be monitored, there may be instances when Rivaroxaban level determination may be necessary (e.g., bleeding, dose adjustment required for renal or hepatic dysfunction).
Rvaroxaban is measured by chromogenic anti-Xa assay.
Specimen Requirements 
Container Light blue (3.2 % sodium citrate) collection tube
Specimen Type Blood
Preferred Collection Volume 3mL
Minimum Collection Volume Adult: 2 mL, Neonates : 2 mL
Collection Instructions When drawing specimens for coagulation testing, always draw a "pilot" tube (7-10ml plain red top tube), completely filled. This removes tissue fluid contamination. Samples should be obtained from peripheral vein wheneever possible. If drawn from indwelling catheter, the line should be flushed with 15mL of saline. After irrigation, a "pilot" tube should be drawn and discarded.
Specimen Handling In-house patients, transport at room temperature.
Out-side client, follow collection instructions and the steps below:
1. Spin light blue top tube. Remove plasma avoiding platelet/buffy coat layer. Spin plasma again to remove top portion of plasma ans place 1mL of PLATELET-POOR PLASMA in plastic tube. (Glass tube unacceptable). Double-centrifugation is critical for accurate results as platelet contamination may cause erroneous results.
2. Plasma must be frozxen within 4 hours of collection. CRITICAL WARNING: Specimens must remain frozen until ready to test. Submit separate aliquots when multiple tests are ordered on the same patient specimen.
Rejection Criteria Hemolysis, clotted, short sample, >4 hrs old (if not frozen), thawed plasma, heparin contamination.
Methodology Chromogenic.
Reference Range See interpretive report
CPT Code(s)
Department Hemostasis/Coagulation
Contact Information Hemostasis Lab; 214-633-4959 Customer Service: 214-633-0400, Toll Free 1-877-887-8136.
Turn Around TimeIn-house - 2 hours; Outside clients1 day.
Performed Sunday-Saturday
Performed by Hemostasis Lab
Updated/Reviewed 07/25/2016