Veripath Test Directory

Epic Test Name FISH, Lymphoma Panel
Synonyms Lymphoma FISH Panel
Description Fluorescence In Situ Hybridization (FISH) is performed to detect BCL6 gene deletion or rearrangements, MYC/IGH, MYC and IGH/BCL2 gene rearrangements.
Specimen Requirements 
Container Green top (Sodium heparin) collection tube.
Specimen Type Bone marrow, blood ,tissue, tissue section.
Preferred Collection Volume 2 mL bone marrow, 5-10 mL blood, 5mm3 tissue; 2 unstained positively charged slides cut at 4 microns and one H&E stain slide
Minimum Collection Volume
Collection Instructions Bone Marrow: 2 mL aspirated bone marrow preferred) anticoagulated with preservative-free sodium heparin (e.g., greenĀ­ top tube). DO NOT use lithium heparin. Bone marrow biopsy may be submitted if aspirate is not available - see instructions for
Specimen Handling Deliver to lab at room temperature within 24 hours. If collected over a weekend, call the laboratory to make arrangements for specimen delivery. May be refrigerated if not transported immediately. Do not freeze. Protect from heat or cold.
Rejection Criteria Frozen, clotted, hemolyzed or grossly contaminated specimens. Incorrect anticoagulant used. Cases submitted without H&E slide.
Methodology See methodology description for FISH test.
Reference Range
CPT Code(s) 88271x8, 88275X4, 88291. If routine Cytogenetics is not requested, add 88237 (bone marrow/blood) or 88239 (tumor).
Department Cytogenetics
Contact Information 214-648-0975 or (214) 645-7057 or Toll free: (877)-887-8136
Turn Around Time1-3 days for fresh specimen, 9 days for FFPE slides.
Performed Sunday-Saturday for fresh specimen, 3 times a week for FFPE slides.
Performed by Cytogenetics
Notes FISH tests can be ordered separately.
Conventional cytogenetic analysis should be performed in addition to FISH at Initial diagnosis.
Updated/Reviewed 12/12/2016