Veripath Test Directory

Epic Test Name FISH, FGFR1
Synonyms FGFR1 FISH
Description Fluorescence in situ hybridization (FISH) is performed to detect the FGFR1 gene rearrangement, most commonly observed in lung cancer.
Specimen Requirements 
Container Green top (Sodium heparin) collection tube.
Specimen Type Bone marrow, blood, tissue.
Preferred Collection Volume 2 mL bone marrow, 5-10 mL blood, 5mm3 tissue.
Minimum Collection Volume
Collection Instructions Bone Marrow: 2 mL aspirated bone marrow preferred) anticoagulated with preservative-free sodium heparin (e.g., greenĀ­ top tube). DO NOT use lithium heparin. Bone marrow biopsy may be submitted if aspirate is not available
Specimen Handling Deliver to lab at room temperature within 24 hours. If collected over a weekend, call the laboratory to make arrangements for specimen delivery. May be refrigerated if not transported immediately. Do not freeze. Protect from heat or cold.
Rejection Criteria Frozen, clotted, hemolyzed or grossly contaminated specimens. Incorrect anticoagulant used. Frozen or fixed tissue specimens, or tissue specimens sent without tissue culture medium.
Methodology A dual color fluorescent labeled DNA probe for the FGFR1 gene, at chromosome band 8p11.2, is hybridized to unstained interphase nuclei on a slide. 200 cells are evaluated to determine whether the signals are rearranged.
Reference Range See interpretive report.
CPT Code(s) 88271x2,88275,88291
Department Cytogenetics
Contact Information Cytogenetics Lab: (214) 648-0975, Customer Service: (214) 645-7057 or Toll Free (877) 887-8136
Turn Around Time1-3 days
Performed Sunday-Saturday
Performed by Cytogenetics
Updated/Reviewed 12/12/2016