Veripath Test Directory

Synonyms MDS FISH panel
Myelodysplastic syndrome FISH panel
Description Fluorescence In situ hybridization (FISH) Is performed to detect chromosome 5 aberrations, chromosome 7 aberrations, gain of chromosome 8, deletions in chromosome 20q and MLL gene rearrangements.
Specimen Requirements 
Container Green top (sodium heparin) collection tube
Specimen Type Bone marrow, blood, tissue
Preferred Collection Volume 2 mL bone marrow, 5-10 ml blood, 5mm³ tissue
Minimum Collection Volume
Collection Instructions 1. Bone Marrow: 2 mL aspirated bone marrow preferred) anticoagulated with preservative-free sodium heparin (e.g., green­ top tube). DO NOT use lithium heparin. Bone marrow biopsy may be submitted if aspirate is not available - see instructions for
Specimen Handling Deliver to lab at room temperature within 24 hours. If collected over a weekend, call the laboratory to make arrangements for specimen delivery. May be refrigerated if not transported immediately. Do not freeze. Protect from heat or cold.
Rejection Criteria
Methodology See methodology description for each FISH test.
Reference Range Frozen, clotted, hemolyzed or grossly contaminated specimens. Incorrect anticoagulant used. Frozen or fixed tissue specimens, or tissue specimens sent without tissue culture medium.
CPT Code(s) 88271x7; 88275x5; 88291
If routine cytogenetics not requested, add 88237 (bone marrow/blood) or 88239 (tumor).
Department Cytogenetics
Contact Information Lab: (214) 648-0975, Customer Service:(214) 645-7057 or Toll free: (877)-887-8136
Turn Around Time1-3 Days
Performed Sunday - Saturday
Performed by Cytogenetics
Notes FISH tests can be ordered separately.

Conventional cytogenetic analysis should be performed in addition to FISH at Initial diagnosis.
Updated/Reviewed 12/12/2016