Veripath Test Directory

Epic Test Name MEK MUTATION ANALYSIS
Components
Synonyms MEK, MAP2K1
Description Codon 56,57,67 Mutations
Specimen Requirements 
Container
Specimen Type Formalin fixed paraffin tissue on slides, whole blood
Preferred Collection Volume 10-micron unstained section, 20 slides
Minimum Collection Volume
Collection Instructions Please contact Molecular Diagnostics lab at 214-648-0960 for more instruction.
Specimen Handling Corresponding pathologist's report must accompany specimen. Formalin-fixed paraffin-embedded (FFPE) unstained slides: 20 unstained sections, each 10-microns thick, corresponding H&E stained 5-micron section required; no mercury¬ based (B-5) fixation; FNA cell blocks should have >25% tumor cells.

Whole blood: ACD yellow top tube is preferred or EDTA purple top tube is acceptable. Fresh specimens must be received in lab within 2 days of collection. Refrigerated (not frozen) samples must be received in lab within 3 days of collection. At least 20% tumor cells are required.
Rejection Criteria Mercury-based fixative (B-5) FFPE specimens. Unstained FFPE sections without corresponding H&E section. Heparinized specimens. FFPE with low % tumor cells. Decalcified bone tissue.
Methodology Mass Spectrometry by Sequenom
Reference Range No Mutation Detected
CPT Code(s) 81402, (88381 or 88387)
Department Molecular Diagnostics
Contact Information Lab: (214)-648-0960
Turn Around TimeInternal Cases: <14 days from order or biopsy date, whichever is later; External Cases: <7 days from order date or receipt of unstained slides, whichever is later.
Performed As requested
Performed by Molecular Diagnostics
Link
Notes
Updated/Reviewed 12/07/2016


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